The wrist-friendly contour of the Adesso vertical mice allows you to hold your hand in a neutral handshake position , minimizing your forearm muscles from twisting and the possible development of Carpal Tunnel Syndrome. Normally, your forearm muscles are twisted from sitting flat on the supporting surface when using a regular mouse. This flat position causes strains on your muscles and leads to wrist pains. This is where the Adesso Vertical Mice become helpful and provide alleviation.